De Quervain’s tenosynovitis is a painful condition affecting the tendons on the thumb side of the wrist. It often results from overuse or repetitive hand and wrist movements, leading to irritation and swelling of the tendons. Symptoms include pain, swelling, and difficulty moving the thumb and wrist. Treatment may involve resting the affected hand, using a splint, applying ice, and taking anti-inflammatory medication. In some cases, corticosteroid injections or surgical intervention may be recommended. Seeking medical evaluation is important for proper diagnosis and management of De Quervain’s tenosynovitis to prevent chronic disability.